Baking soda is a natural drain cleaner! Measure 1/2 cup baking soda and 1/2 cup vinegar. Pour the baking soda into the drain first, followed by the vinegar. It will bubble furiously. Follow with two quarts of hot water. Please do not use this method if you have recently used commercial drain cleaners. Eliminating drain cleaners from your home is a giant step toward a greener home, as they are among the most dangerous household chemicals available.